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World J Biol Chem. Nov 26, 2015; 6(4): 351-357
Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.351
Klotho in cardiovascular disease: Current and future perspectives
Javier Donate-Correa, Ernesto Martín-Núñez, Carmen Mora-Fernández, Mercedes Muros-de-Fuentes, Nayra Pérez-Delgado, Juan F Navarro-González
Javier Donate-Correa, Ernesto Martín-Núñez, Carmen Mora-Fernández, Juan F Navarro-González, Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Mercedes Muros-de-Fuentes, Nayra Pérez-Delgado, Clinical Biochemistry Service, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Juan F Navarro-González, Nephrology Service, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Author contributions: Donate-Correa J, Martín-Núñez E, Mora-Fernández C, Muros-de-Fuentes M and Pérez-Delgado N cooperated in the design and the writing; Navarro-González JF revised and polished the text.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Javier Donate-Correa, PhD, Research Unit, University Hospital Nuestra Señora de Candelaria, Ctra. Gral. del Rosario, 145, 38010 Santa Cruz de Tenerife, Spain. jdonate@ull.es
Telephone: +34-922-602061 Fax: +34-922-600562
Received: May 28, 2015
Peer-review started: May 28, 2015
First decision: July 20, 2015
Revised: July 31, 2015
Accepted: September 7, 2015
Article in press: September 8, 2015
Published online: November 26, 2015
Processing time: 178 Days and 17.1 Hours
Abstract

Protein Klotho, beyond its role as a regulator of the phosphatemia, is also involved in the maintaining of the cardiovascular health, being associated its alterations with the development of cardiovascular damage and increased morbi-mortality. For all this, nowadays Klotho is the subject of a thorough research which is focused on uncover its intimate mechanisms of action, and in analyzing the utility of its modulation as a potential strategy with clinical applicability. Molecular mechanisms of Klotho are not well understood but an emerging research area links Klotho deficiency with vascular pathology. Changes in this protein have been associated with cardiovascular-related complications like inflammation, vascular calcification, and endothelial dysfunction. All this is particularly relevant if considering the recent discovery of Klotho expression in vascular tissue.

Keywords: Klotho; Cardiovascular disease; Chronic kidney disease; Mechanism of action; Therapeutics

Core tip: Protein Klotho, beyond its role as a regulator of the phosphatemia, has also been involved in the maintaining of the cardiovascular health. For all this, is the subject of a thorough research which focused on uncover its intimate mechanisms of action, and in analyzing the utility of its modulation as a potential strategy for clinical applicability. Emerging research links Klotho deficiency with vascular pathology. Changes in this protein have been associated, among others cardiovascular-related complications, with inflammation, vascular calcification, and endothelial dysfunction.