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©The Author(s) 2025.
World J Gastrointest Surg. Jun 27, 2025; 17(6): 103674
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.103674
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.103674
Table 1 Demographic and clinical characteristics of the study population, mean ± SD/n (%)
Characteristic | All patients (n = 100) | Benign GIST (n = 43) | Malignant GIST (n = 57) | P value |
Age (years) | 62.3 ± 11.4 | 60.8 ± 12.1 | 63.5 ± 10.8 | 0.235 |
Sex | 0.412 | |||
Male | 57 (57.0) | 23 (53.5) | 34 (59.6) | |
Female | 43 (43.0) | 20 (46.5) | 23 (40.4) | |
Tumor location | 0.028 | |||
Stomach | 65 (63.1) | 33 (73.3) | 32 (55.2) | |
Small intestine | 28 (27.2) | 8 (17.8) | 20 (34.5) | |
Other | 10 (9.7) | 4 (8.9) | 6 (10.3) | |
Tumor size (cm) | 4.8 ± 2.9 | 3.2 ± 1.4 | 6.1 ± 3.1 | < 0.001 |
Presenting symptoms | 0.156 | |||
Asymptomatic | 42 (42.0) | 22 (51.2) | 20 (35.1) | |
Abdominal pain | 35 (35.0) | 13 (30.2) | 22 (38.6) | |
GI bleeding | 15 (15.0) | 5 (11.6) | 10 (17.5) | |
Other | 8 (8.0) | 3 (7.0) | 5 (8.8) |
Table 2 Conventional ultrasound features of benign and malignant gastrointestinal stromal tumors, n (%)
Feature | Benign GIST (n = 45) | Malignant GIST (n = 58) | P value |
Shape | < 0.001 | ||
Regular | 38 (84.4) | 25 (43.1) | |
Irregular | 7 (15.6) | 33 (56.9) | |
Boundary | 0.002 | ||
Clear | 41 (91.1) | 39 (67.2) | |
Unclear | 4 (8.9) | 19 (32.8) | |
Echo pattern | < 0.001 | ||
Homogeneous | 36 (80.0) | 22 (37.9) | |
Heterogeneous | 9 (20.0) | 36 (62.1) | |
Vascularity | < 0.001 | ||
Grade 0-1 | 35 (77.8) | 19 (32.8) | |
Grade 2-3 | 10 (22.2) | 39 (67.2) |
Table 3 Strain elastography parameters for benign and malignant gastrointestinal stromal tumors, mean ± SD/n (%)
Parameter | Benign GIST (n = 45) | Malignant GIST (n = 58) | P value |
Elastographic pattern | < 0.001 | ||
Score 1-2 | 33 (73.3) | 8 (13.8) | |
Score 3 | 9 (20.0) | 15 (25.9) | |
Score 4-5 | 3 (6.7) | 35 (60.3) | |
Strain ratio | 2.31 ± 0.89 | 4.82 ± 1.73 | < 0.001 |
Strain pattern | < 0.001 | ||
Homogeneous | 38 (84.4) | 20 (34.5) | |
Heterogeneous | 7 (15.6) | 38 (65.5) |
Table 4 Shear-wave elastography parameters for benign and malignant gastrointestinal stromal tumors, mean ± SD
Parameter | Benign GIST (n = 45) | Malignant GIST (n = 58) | P value |
Mean elastic modulus (kPa) | 21.3 ± 8.4 | 45.6 ± 15.8 | < 0.001 |
Maximum elastic modulus (kPa) | 28.7 ± 10.2 | 62.4 ± 20.3 | < 0.001 |
Minimum elastic modulus (kPa) | 15.2 ± 6.8 | 31.8 ± 12.4 | < 0.001 |
Heterogeneity index | 0.18 ± 0.07 | 0.42 ± 0.15 | < 0.001 |
Table 5 Diagnostic performance of elastography parameters
Parameter | AUC (95%CI) | Cutoff value | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) |
Strain ratio | 0.892 (0.831-0.953) | 3.45 | 84.5 | 86.7 | 89.1 | 81.2 |
Mean elastic modulus | 0.918 (0.865-0.971) | 32.5 | 87.9 | 88.9 | 91.1 | 85.1 |
Heterogeneity index | 0.876 (0.810-0.942) | 0.28 | 82.8 | 84.4 | 87.3 | 79.2 |
- Citation: Xu H, Liu JR, Gao BJ, Peng L, Han ZQ, Zhang RX. Ultrasound elastography for the differential diagnosis of benign and malignant gastrointestinal stromal tumors. World J Gastrointest Surg 2025; 17(6): 103674
- URL: https://www.wjgnet.com/1948-9366/full/v17/i6/103674.htm
- DOI: https://dx.doi.org/10.4240/wjgs.v17.i6.103674