Copyright ©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Mar 27, 2016; 8(3): 274-283
Published online Mar 27, 2016. doi: 10.4240/wjgs.v8.i3.274
Post-operative abdominal complications in Crohn’s disease in the biological era: Systematic review and meta-analysis
Peter Waterland, Thanos Athanasiou, Heena Patel
Peter Waterland, Heena Patel, Department of Colorectal Surgery, Worcester Royal Hospital, Worcester, WR5 1DD, United Kingdom
Thanos Athanasiou, Department of Biosurgery and Surgical Technology, Imperial College London, London, W2 1NY, United Kingdom
Author contributions: Waterland P acquisition of data, analysis and interpretation, drafting article, final approval; Athanasiou T biostatistical analysis and interpretation, drafting article, final approval; Patel H conception and design of study, acquisition of data, analysis and interpretation of data, drafting article, final approval.
Conflict-of-interest statement: The authors deny any conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Heena Patel, MD, FRCS, Consultant Surgeon, Department of Colorectal Surgery, Worcester Royal Hospital, Charles Hastings Way, Worcester, WR5 1DD, United Kingdom.
Telephone: +44-1905-763333
Received: August 8, 2015
Peer-review started: August 11, 2015
First decision: October 16, 2015
Revised: December 17, 2015
Accepted: December 29, 2015
Article in press: January 4, 2016
Published online: March 27, 2016
Core Tip

Core tip: Pre-operative use of anti-tumor necrosis factor alpha (TNF-α) therapy increases risks of post-operative infectious complications after surgery for Crohn’s disease, particularly wound sepsis. Surgery should be planned carefully and ideally performed after appropriate cessation of anti-TNF-α therapy to mitigate increased post-operative risks.