Published online Mar 27, 2016. doi: 10.4240/wjgs.v8.i3.266
Peer-review started: September 1, 2015
First decision: September 29, 2015
Revised: December 12, 2015
Accepted: January 5, 2016
Article in press: January 7, 2016
Published online: March 27, 2016
Core tip: Fibrin sealant use in pilonidal disease treatment may involve filling in the sinus tracts, covering the laid-open area after excision, or obliterating the subcutaneous dead space before skin closure. This systematic review demonstrates that when the fibrin sealant was used to obliterate the subcutaneous dead space, there was no reduction in wound complications. It was unadvisable to fill the sinus tracts because it was not superior to the other more cost-effective treatments with a 20% recurrence rate. More studies are necessary for sealant use in covering the laid-open area, which has promising results, predicting shorter wound healing time and increased patient satisfaction.