Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2025; 17(6): 107086
Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.107086
Long-term survival with multimodal treatment including conversion surgery for locally advanced esophageal neuroendocrine carcinoma: A case report
Kazuya Okamoto, Kentoku Fujisawa, Kei Kono, Yusuke Ogawa, Hayato Shimoyama, Shusuke Haruta, Yutaka Takazawa, Masaki Ueno, Harushi Udagawa
Kazuya Okamoto, Kentoku Fujisawa, Yusuke Ogawa, Hayato Shimoyama, Shusuke Haruta, Masaki Ueno, Harushi Udagawa, Department of Gastroenterological Surgery, Toranomon Hospital, Tokyo 105-8470, Tōkyō, Japan
Kei Kono, Yutaka Takazawa, Department of Pathology, Toranomon Hospital, Tokyo 105-8470, Tōkyō, Japan
Author contributions: Okamoto K and Fujisawa K designed the case report and drafted the manuscript; Kono K and Takazawa Y acquired data; Okamoto K, Fujisawa K, Ogawa Y, Shimoyama H, Haruta S, Ueno M, and Udagawa H managed the patient’s care and acquired data; Fujisawa K, Ueno M, and Udagawa H supervised the work; and all authors have reviewed the manuscript and read and approved the final manuscript.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kentoku Fujisawa, MD, Department of Gastroenterological Surgery, Toranomon Hospital, 2-2-2 Toranomon, Minato-ku, Tokyo 105-8470, Tōkyō, Japan. fkentoku@gmail.com
Received: March 18, 2025
Revised: April 4, 2025
Accepted: May 14, 2025
Published online: June 27, 2025
Processing time: 73 Days and 11 Hours
Core Tip

Core Tip: We used a multimodal treatment approach for locally advanced unresectable esophageal neuroendocrine carcinoma (NEC). Two aspects of this case are noteworthy. First, because NEC was finally diagnosed through postoperative pathological examination, the chemotherapy was administered based on the initial presumption of squamous cell carcinoma. This facilitated complete resolution of the squamous cell carcinoma component, allowing for subsequent targeting of the remaining NEC component. Second, following chemotherapy, no new distant metastases developed, with effective tumor control for the primary lesion and metastatic lymph nodes. Thus, surgery can be effective if resection is feasible, even for locally advanced NEC.