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World J Gastrointest Surg. Jul 27, 2021; 13(7): 678-688
Published online Jul 27, 2021. doi: 10.4240/wjgs.v13.i7.678
Gastrectomy impact on the gut microbiome in patients with gastric cancer: A comprehensive review
Vaidota Maksimaityte, Augustinas Bausys, Marius Kryzauskas, Martynas Luksta, Ieva Stundiene, Klaudija Bickaite, Bernardas Bausys, Tomas Poskus, Rimantas Bausys, Kestutis Strupas
Vaidota Maksimaityte, Augustinas Bausys, Marius Kryzauskas, Martynas Luksta, Ieva Stundiene, Tomas Poskus, Rimantas Bausys, Kestutis Strupas, Clinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius 03101, Lithuania
Augustinas Bausys, Rimantas Bausys, Department of Abdominal Surgery and Oncology, National Cancer Institute, Vilnius 08660, Lithuania
Klaudija Bickaite, Bernardas Bausys, Faculty of Medicine, Vilnius University, Vilnius 03101, Lithuania
Author contributions: Maksimaityte V and Bausys A contributed equally to this work; Bausys R and Strupas K conceptualized and designed the work; Maksimaityte V, Bausys A, Kryzauskas M, Luksta M, Stundiene I, Bickaite K, Bausys B, and Poskus T performed the literature review and critical revision of the studies; Bausys A and Maksimaityte V prepared the manuscript; Kryzauskas M, Luksta M, Stundiene I, Bickaite K, Bausys B, Poskus T, Bausys R, and Strupas K revised the manuscript; all authors read and approved the final version of the manuscript.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Augustinas Bausys, MD, Doctor, Clinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Ciurlionio str. 21, Vilnius 03101, Lithuania. abpelikanas@gmail.com
Received: March 13, 2021
Peer-review started: March 13, 2021
First decision: April 6, 2021
Revised: April 19, 2021
Accepted: May 25, 2021
Article in press: May 25, 2021
Published online: July 27, 2021
Core Tip

Core Tip: In most cases of gastric cancer (GC) the only life-saving treatment is gastrectomy. Gastrectomy results in significant changes in gut microbiota: Higher abundance of oral cavity bacteria, aero-tolerant bacteria, and bile transforming bacteria, and these changes in the microbiome are related to host health. In this review we discuss current knowledge and the results of recent studies on the changes in gut microbiome after gastrectomy in patients with a history of GC.