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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Prognostic significance of preoperative lymphocyte to monocyte ratio in patients with signet ring gastric cancer
He-Li Liu, Xiang Feng, Mi-Mi Tang, Hai-Yan Zhou, Huan Peng, Jie Ge, Ting Liu
He-Li Liu, Xiang Feng, Jie Ge, Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
He-Li Liu, The Hunan Provincial Key Laboratory of Precision Diagnosis and Treatment for Gastrointestinal Tumor, The Hunan Provincial Key Laboratory of Precision Diagnosis and Treatment for Gastrointestinal Tumor, Changsha 410008, Hunan Province, China
Mi-Mi Tang, Ting Liu, Institute for Rational and Safe Medication Practices National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Hai-Yan Zhou, Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Huan Peng, Clinical Nursing Teaching and Research Section, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China
Author contributions: Liu HL, Feng X contributed equally to this work; Liu HL, Feng X and Ge J designed research; Tang MM, Zhou HY and Feng X collected and analyzed clinical data; Liu T, Peng H wrote the paper.
Supported by the Clinical Research Fund of National Geriatric Disease Clinical Medical Research Center, No. 2022LNJ22; Guangdong Yiyang Healthcare Charity Foundation, No. JZ2022014.
Institutional review board statement: The study was reviewed and approved by the Xiangya Hospital, Central South University Institutional Review Board [Approval No. Xykyll-lx-2019030510].
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Jie Ge, MD, Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. gejie@csu.edu.cn
Received: May 6, 2023
Peer-review started: May 6, 2023
First decision: May 19, 2023
Revised: May 31, 2023
Accepted: June 21, 2023
Article in press: June 21, 2023
Published online: August 27, 2023
ARTICLE HIGHLIGHTS
Research background
The incidence of signet ring gastric carcinoma has increased among the past decades. Several inflammation indexes, including ratio of lymphocytes to monocytes (LMR), have been shown to be effective predictors of gastric cancer prognosis.
Research motivation
The predictive accuracy of ratio of LMR for signet ring gastric cancer is unclear now.
Research objectives
To assess the prognosis predictive accuracy of preoperative LMR for signet ring gastric cancer.
Research methods
Our research center conducted a retrospective analysis of clinical data from patients diagnosed with signet ring gastric carcinoma over the past 5 years, identifying factors that significantly affect patients’ survival by using single factor analysis, and deciding independent prognostic factors related to signet ring cell gastric cancer by using multivariate analysis.
Research results
The results of the single factor analysis indicated a strong correlation between the survival of signet ring gastric cancer patients and several factors, including tumour invasion, lymph node metastasis, pTNM stage, surgical approach, age, carcinoembryonic antigen (CEA), platelet-to-lymphocyte ratio (PLR), LMR, ALB, PNI and FIB. Furthermore, the multivariate analysis revealed that age, tumor invasion depth, pTNM stage, preoperative CEA level, and preoperative LMR level were independent factors related to the prognosis of signet ring gastric cancer.
Research conclusions
In signet ring gastric cancer patients, a low preoperative LMR level is indicative of a poor prognosis. The death risk ratio of the low LMR group compared to the high LMR group is 1.776.
Research perspectives
The study subjects were followed up for 5 years and divided into survival group and death group. Clinical data, pathological data, and prognosis of the two groups of patients were observed.
