Published online Mar 27, 2021. doi: 10.4240/wjgs.v13.i3.256
Peer-review started: November 3, 2020
First decision: December 20, 2020
Revised: December 23, 2020
Accepted: January 28, 2021
Article in press: January 28, 2021
Published online: March 27, 2021
There have been different reports on mortality of sepsis, but few focus on the prognosis of patients with sepsis after surgery.
To explore the prognostic predictors in patients with sepsis after gastrointestinal tumor surgery.
We studied the clinical features and prognostic predictors in patients with sepsis after gastrointestinal tumor surgery in intensive care unit (ICU).
We retrospectively screened patients who underwent gastrointestinal tumor surgery at Peking University Cancer Hospital from January 2015 to December 2019. Among them, 181 patients who were diagnosed with sepsis in ICU were included in our study. Survival was analysed by the Kaplan-Meier method. Univariate and multivariate adjusted analyses were performed to identify predictors of prognosis.
The 90-d all-cause mortality rate was 11.1% in our study. In multiple analysis, we found that body mass index (BMI) ≤ 20 kg/m2, lactic acid after ICU admission, and sequential organ failure assessment (SOFA) score within 24 h after ICU admission might be independent risk predictors of the prognosis of sepsis after gastrointestinal tumor surgery. Compared with SOFA score, SOFA score combined with BMI and lactic acid might have higher predictive ability (area under the receiver operating characteristic curve, 0.859; 95% confidence interval, 0.789-0.929).
Lactic acid and SOFA score within 24 h after ICU admission are independent risk predictors of the prognosis of sepsis after gastrointestinal tumor surgery. SOFA score combined with BMI and lactic acid might have good predictive value.
More large-scale studies are needed in the future to confirm these results.