Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Share the Article
Abudouhadier K, Xu JQ, Lin H. Value of pancreatic duct stent placement combined with octreotide for reducing the postoperative pancreatic fistula rate in patients with diabetes undergoing pancreaticoduodenectomy. World J Gastrointest Surg 2026; 18(11): 123131 [DOI: 10.4240/wjgs.123131]
World J Gastrointest Surg. Nov 27, 2026; 18(11): 123131 Published online Nov 27, 2026. doi: 10.4240/wjgs.123131
Value of pancreatic duct stent placement combined with octreotide for reducing the postoperative pancreatic fistula rate in patients with diabetes undergoing pancreaticoduodenectomy
Kaisaier Abudouhadier, Jia-Qi Xu, Hai Lin
Kaisaier Abudouhadier, Department of Emergency Trauma Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830013, Xinjiang Uygur Autonomous Region, China
Jia-Qi Xu, Hai Lin, Department of Pancreatic Surgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi 830013, Xinjiang Uygur Autonomous Region, China
Author contributions: Abudouhadier K participated in study design, clinical data collection and data analysis, drafted the initial manuscript; Xu JQ conducted data sorting and result interpretation, critically revised the important academic content of the manuscript; Lin H was responsible for the overall design and supervision of the research, performed critical revision of the manuscript; all authors have read and approved the final version of the manuscript; all authors agree to take responsibility for all aspects of the work, and ensure that any issues related to the accuracy or integrity of any part of the study are properly investigated and resolved.
AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Institutional review board statement: The research was reviewed and approved by The First Affiliated Hospital of Xinjiang Medical University
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: No conflict of interest is associated with this work.
Data sharing statement: No other data available.
Corresponding author: Hai Lin, Chief, Department of Pancreatic Surgery, The First Affiliated Hospital of Xinjiang Medical University, No. 137 South Liyushan Road, Xinshi District, Urumqi 830013, Xinjiang Uygur Autonomous Region, China. 13639966260@163.com
Received: May 9, 2026 Revised: June 12, 2026 Accepted: June 29, 2026 Published online: November 27, 2026 Processing time: 186 Days and 19 Hours
Abstract
BACKGROUND
Pancreaticoduodenectomy (PD) carries high postoperative complication risks, and postoperative pancreatic fistula is most common. Diabetes further elevates this risk due to impaired healing and immunity. Pancreatic duct stents and octreotide are widely used for prevention, but relevant studies targeting diabetic patients remain insufficient. This study explored the combined application of the two interventions.
AIM
To investigate the effect of combined therapy on postoperative pancreatic fistula in diabetic PD patients.
METHODS
Data from 156 patients with diabetes who underwent PD at our hospital from January 2022 to September 2025 were collected. The patients were divided into a combination group and a control group. In the control group, pancreatic duct stent was placed intraoperatively and routine postoperative care was given. In the combination group, intravenous octreotide infusion was added postoperatively. The incidence of postoperative pancreatic fistula, duration of drain retention, glycemic variability, and length of hospital stay were compared between the two groups.
RESULTS
A total of 60 patients were included in each group, and baseline characteristics were comparable. The incidence of postoperative pancreatic fistula in the combination group was 11.7%, significantly lower than that in the control group (23.3%; odds ratio = 0.43, 95%CI: 0.21-0.89, P = 0.022). The combination group also had significantly shorter drain retention days (8.8 ± 3.5 days vs 12.1 ± 4.8 days, P = 0.018) and postoperative hospital stay (14.5 ± 5.3 days vs 19.2 ± 7.1 days, P = 0.026). No significant inter-group differences were found in mean blood glucose, blood glucose coefficient of variation, daily insulin dosage and the incidence of hypoglycemic events (all P > 0.05).
CONCLUSION
In diabetic patients undergoing PD, the combined regimen was associated with a reduced incidence of postoperative pancreatic fistula, shorter drainage duration, and a shorter hospital stay without significantly affecting postoperative glycemic variability.
Core Tip: This propensity score-matched study in diabetic patients undergoing pancreaticoduodenectomy shows that adding postoperative octreotide to pancreatic duct stent placement significantly reduces clinically relevant postoperative pancreatic fistula (11.7% vs 23.3%), shortens drain retention and hospital stay, and does not affect overall postoperative glucose metabolism. The combined mechanical and pharmacological approach appears safe and beneficial for the type 2 diabetic patients included in this single-center retrospective cohort.
