Wang M, Sun J, Song ZQ, Chen XQ, Xie GD, Zhu Y, Zhou YK. Giant transverse colonic mesenteric mucinous liposarcoma combined with rectal cancer and aortic coarctation: A case report and review of literature. World J Gastrointest Surg 2025; 17(6): 107866 [DOI: 10.4240/wjgs.v17.i6.107866]
Corresponding Author of This Article
Yong-Kun Zhou, Chief Physician, Department of General Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369 Jingshi Road, Jinan 250014, Shandong Province, China. zhouyongkun03107@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Meng Wang, Zhi-Qiang Song, Xi-Qi Chen, Guang-Dong Xie, Yong Zhu, Yong-Kun Zhou, Department of General Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
Jian Sun, First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong Province, China
Co-first authors: Meng Wang and Jian Sun.
Co-corresponding authors: Yong-Kun Zhou and Yong Zhu.
Author contributions: Wang M and Sun J drafted the manuscript and collected the data; Song ZQ, Chen XQ and Xie GD analyzed and collated the data; Zhou Y and Zhou YK guided the operation and revised the manuscript; all authors have read and agreed to the published version of the manuscript.
Supported by The Shandong Natural Science Foundation of China, No. ZR2021QH046.
Informed consent statement: According to local regulations, this study was approved by the Institutional Review Board or provided consent to participate. Informed written consent was obtained from the patient’s next of kin for the publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Kun Zhou, Chief Physician, Department of General Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369 Jingshi Road, Jinan 250014, Shandong Province, China. zhouyongkun03107@126.com
Received: March 30, 2025 Revised: April 19, 2025 Accepted: May 7, 2025 Published online: June 27, 2025 Processing time: 61 Days and 21.7 Hours
Abstract
BACKGROUND
Liposarcomas (LPSs) are malignant mesenchymal tumors originating from adipocytes. Myxoid LPS (MLPS), a common subtype, predominantly arises in the extremities, retroperitoneum, and deep soft tissues, with a rare occurrence in the gastrointestinal tract. Primary mesenteric LPS is particularly uncommon, especially in the transverse colonic mesentery.
CASE SUMMARY
This report describes the case of a 65-year-old female patient who presented with abdominal distension and was diagnosed with a giant mucinous LPS of the transverse colonic mesentery. Upon admission, the patient underwent a comprehensive evaluation. Contrast-enhanced computed tomography (CT) of the chest and abdomen revealed a large malignant tumor with aortic dissection, while colonoscopy identified rectal cancer. Given the patient's condition and surgical risk, an interventional procedure was first performed to manage the aortic coarctation, followed by tumor resection via laparotomy. Intraoperative and histopathological findings confirmed a giant mucinous LPS originating from the transverse colon mesentery. Postoperatively, the patient underwent chemotherapy and regular follow-up CT. Although the rectal tumor did not recur, the mesenteric tumor showed extensive recurrence, compressing the intestinal lumen and causing mechanical obstruction, which severely threatened the patient's life. A second operation temporarily relieved the obstructive symptoms; however, it had a limited effect on tumor progression. The patient died four months later due to disease progression.
CONCLUSION
While no standardized treatment exists for MLPS co-occurring with multiple diseases, operation remains the mainstay. However, recurrence, metastasis, and poor postoperative prognosis continue to pose serious threats to patient survival.
Core Tip: To the best of our knowledge, this is the first reported case of a giant mucinous liposarcomas (LPSs) of the transverse colonic mesentery coexisting with rectal cancer and aortic coarctation. This case contributes valuable clinical insight and highlights the unfavorable outcomes of recurrent and metastatic myxoid LPS.
