Published online Jun 27, 2025. doi: 10.4240/wjgs.v17.i6.106069
Revised: March 17, 2025
Accepted: April 28, 2025
Published online: June 27, 2025
Processing time: 104 Days and 23.2 Hours
Gastric subepithelial lesions (SELs) are elevated lesions originating from the muscularis mucosa, submucosa, or muscularis propria, and may also include extraluminal lesions. For small SELs (less than 5 cm), complete endoscopic exci
To evaluate the efficacy of the interrupted closure technique compared to the traditional closure technique in EFTR for gastric SELs.
This single-center, prospective, randomized controlled trial was conducted at a tertiary hospital from September 2023 to September 2024. A total of 90 patients who underwent EFTR for gastric SELs were randomly allocated to either the in
All patients had complete resection and wound closure without any severe postoperative complications. The incidence of intraoperative gas-related complications was significantly lower in the interrupted closure group than in the traditional closure group (2.27% vs 26.09%, P = 0.001), demonstrating interrupted closure technique can reduce the incidence of gas-related issues. Statistical analysis revealed that the incidence of postoperative infection was significantly lower in the experimental group than in the control group (15.91% vs 41.30%, P = 0.008). Ad
The interrupted closure technique in EFTR for treating gastric SELs is safe and effective, reducing the incidence of intraoperative gas complications and postoperative infections.
Core Tip: The interrupted closure technique involves performing a two-thirds circumferential full-thickness incision around the diseased gastric wall, followed by the immediate closure of either the proximal or distal end of the defect using metallic clips. With minimal necessary exposure, lesion dissection and defect closure are performed alternately until complete tumor resection and wound closure are achieved. Our study findings demonstrate that this technique is an effective approach for the treatment of gastric subepithelial lesions, significantly reducing the incidence of intraoperative gas-related complications and postoperative infections compared to traditional endoscopic full-thickness resection.