Impact of creatinine methodology on glomerular filtration rate estimation in diabetes

Table 1 Kidney Disease Improving Global Guidelines-2012 Prognostic Categories of Chronic Kidney Disease according to estimated glomerular filtration rate and albuminuria (adapted from the Reference 2)

		Albuminuria categories [albumin/creatinine (mg/mmol)]
		A1	A2	A3
		< 3	3-30	≥ 30
		Normal to mildly increased	Moderately increased	Severely increased
eGFR categories (mL/min per 1.73 m2)	G1, ≥ 90	Low risk	Moderately increased risk	High risk
	Normal/high
	G2, 60-90	Low risk	Moderately increased risk	High risk
	Mildly decreased
	G3a, 45-59	Moderately increased risk	High risk	Very high risk
	Mildly to moderately decreased
	G3b, 30-44	High risk	Very high risk	Very high risk
	Moderately to severely decreased
	G4, 15-29	Very high risk	Very high risk	Very high risk
	Severely decreased
	G5, < 15	Very high risk	Very high risk	Very high risk
	Kidney failure

eGFR: Estimated glomerular filtration rate.

Table 2 Clinical characteristics of the study subjects across the Kidney Disease Improving Global Guidelines-2012 categories of albuminuria

	Category of Albuminuria
	A1	A2	A3
N (M/F)	372 (212/198)	166 (87/79)	72 (38/34)
Age (yr)	63 (19-88)	68 (18-88)	60a,b (29-85)
Glucose (mmol/L)	9.0 (8.8-9.3)	9.4 (8.9-10.0)	7.4a,b (5.7-8.9)
HbA1c (%)	7.4 (7.3-7.6)	7.5 (7.3-7.7)	7.8 (7.4-8.5)
HbA1c (mmol/mol)	59 (57-61)	59 (57-61)	62 (58-71)
e-SCr (μmol/L)	69b,d (66-72)	75a,d (72-77)	100a,b (88-137)
cJ-SCr (μmol/mol)	70b,d (67-72)	77a,d (72-81)	108a,b (87-140)
e-SCr-eGFR (mL/min per 1.73 m2)	91b,d (88-93)	85a,d (80-88)	60a,b (39-77)
cJ-SCr-eGFR (mL/min per 1.73 m2)	90b,d (87-92)	83a,d (76-86)	55a,b (39-73)

Age is expressed as median (range) and other variables as median (95%CI of median).

^aP < 0.001 vs A1;

^bP < 0.001 vs A2;

^dP < 0.001 vs A3. HbA_1c: Glycosylated hemoglobin; SCr: Serum creatinine; eGFR: Estimated glomerular filtration rate; e: Enzymatic; cJ: Compensated Jaffé; M: Male; F: Female.

Table 3 Reclassification of the estimated glomerular filtration rate based chronic kidney disease stage according to enzymatic and compensated Jaffé creatinine values

		e-SCr-eGFR-based CKD stage
		1	2	3A	3B	4	Total
cJ-SCr-eGFR-based CKD stage	1	2721	52	01	01	01	277 (42.7)
	2	253	2061	22	01	01	233 (36)
	3a	01	233	541	01	01	77 (11.9)
	3b	01	01	53	281	12	34 (5.2)
	4	01	01	01	13	261	27 (4.2)
	Total	297 (45.8)	234 (36.1)	61 (9.4)	29 (4.5)	27 (4.2)	648

¹Concordant;

²Negatively discordant;

³Positively discordant cases. CKD: Chronic kidney disease; cJ-SCr-eGFR: Compensated Jaffé serum creatinine-based estimated glomerular filtration rate.