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Copyright ©The Author(s) 2015.
World J Diabetes. Feb 15, 2015; 6(1): 8-16
Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.8
Table 1 Clinical trials investigating insulin sensitivity as a therapeutic target in type 1 diabetes
Clinical trial name(s) Description
Metformin Vascular Adverse Lesions in Type 1 Diabetes (REMOVAL) trial (NCT01483560)Double-blind RCT with metformin to improve insulin sensitivity in subjects with T1D in an attempt to prevent vascular complications
Effects of Metformin On Cardiovascular Function In Adolescents with Type 1 Diabetes (EMERALD) study (NCT01808690)Double-blind RCT with metformin to evaluate if metformin will improve tissue-specific insulin resistance in T1D adolescents using the hyperinsulinemic-euglycemic clamp technique, as well as improve vascular, cardiac, exercise and muscle mitochondrial function
Insulin Clamp Ancillary Study for Assessment of Insulin Resistance (NCT02045290)Assess if metformin will improve tissue-specific insulin resistance in type 1 diabetes using hyperinsulinemic euglycemic clamps
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes (NCT01881828)Evaluate the efficacy and safety of the use of metformin in addition to standard insulin therapy in overweight and obese children and adolescents, age 12 - < 20 yr, with type 1 diabetes for at least 1 yr
Effect of Metformin on Vascular and Mitochondrial Function in Type 1 Diabetes (MeT1, NCT01813929)Measure the effect of insulin sensitivity vascular function and compliance, and mitochondrial function in T1D