Toll-like receptor expression and signaling in human diabetic wounds

Table 1 Toll-like receptor pathway genes expressed in debridement wound tissue

Gene	Non-diabetic woundsmRNA/18s ratio	Diabetic wounds mRNA/18s ratioa
TLR1	0.6 ± 0.1	1.9 ± 0.4
TLR2	1.2 ± 0.3	3.6 ± 0.5
TLR4	1.3 ± 0.2	3.8 ± 0.2
TLR6	0.2 ± 0.1	2 ± 0.5
MyD88	1.4 ± 0.2	3.1 ± 0.4
IRAK-1	1.1 ± 0.1	2.8 ± 0.6
MD2	0.2 ± 0.04	1.6 ± 0.3
NF-κB	0.8 ± 0.05	2.3 ± 0.2
TNF-α	1 ± 0.4	2.6 ± 0.6

Human diabetic wounds (n = 8) show significantly higher mRNA/18s ratio compared to non-diabetic wounds (n = 4) (^aP < 0.05 vs non-diabetic wounds). TLR: Toll-like receptor.