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World J Diabetes. Apr 15, 2014; 5(2): 219-223
Published online Apr 15, 2014. doi: 10.4239/wjd.v5.i2.219
Published online Apr 15, 2014. doi: 10.4239/wjd.v5.i2.219
Toll-like receptor expression and signaling in human diabetic wounds
Mohan R Dasu, Department of Dermatology, University of California at Davis, Davis, CA 95816, United States
Sandra J Martin, McClellan Outpatient Clinic, V A Northern California Health Care System, Sacramento, CA 95652, United States
Author contributions: All authors contributed to this work.
Correspondence to: Mohan R Dasu, PhD, Department of Dermatology, University of California at Davis, 3301 C Street, Sacramento, CA 95816, United States. ravi.dasu@ucdmc.ucdavis.edu
Telephone: +1-530-7528153 Fax: +1-530-7529766
Received: September 25, 2013
Revised: January 28, 2014
Accepted: March 17, 2014
Published online: April 15, 2014
Revised: January 28, 2014
Accepted: March 17, 2014
Published online: April 15, 2014
Core Tip
Core tip: Increased TLR2/4-MyD88-nuclear factor-kappa B expression and signaling with attendant oxidative stress may contribute to the hyperinflammation frequently seen in human diabetic wounds.