Copyright
©The Author(s) 2021.
World J Diabetes. Nov 15, 2021; 12(11): 1812-1817
Published online Nov 15, 2021. doi: 10.4239/wjd.v12.i11.1812
Published online Nov 15, 2021. doi: 10.4239/wjd.v12.i11.1812
Ref. | Year | Country | Follow-up timing | Main outcomes |
Rowan et al[11] | 2011 | Australia and New Zealand | 2 yr | Metformin exposed children had (1) Larger mid-upper arm circumferences, biceps and subscapular skinfold thickness; and (2) Total fat mass and percentage body fat were similar to insulin group |
Rowan et al[13] | 2018 | Australia and New Zealand | 7 yr and 9 yr in Adelaide and Auckland cohort respectively | No difference in the metformin-exposed children and insulin-treated mothers in Adelaide cohort. In Auckland cohort: (1) Metformin-exposed children had larger weight, arm and waist circumferences, and waist: Height ratio; (2) Similar body fat percentage between two treatment groups; and (3) Visceral adipose tissue, abdominal subcutaneous adipose tissue and liver fat were similar in metformin exposed group in comparison to insulin treatment |
Ijäs et al[14] | 2014 | Finland | mo | (1) Children exposed to metformin were significantly heavier at the age of 12 mo; and (2) Metformin exposed offspring were taller and heavier at the age of 18 mo |
Landi et al[15] | 2019 | New Zealand | 4 yr | No significant differences in weight, weight for height, or body mass index in children of insulin versus metformin exposed mothers |
Paul et al[16] | 2020 | India | 9 yr | (1) No difference in weight, body mass index, waist circumference, body fat percentages in between metformin and glibenclamide exposed children; and (2) Similar metabolic profile between two groups except mild elevation of serum triglyceride in the metformin group |
- Citation: Roy A, Sahoo J. Long-term effects of metformin use in gestational diabetes mellitus on offspring health. World J Diabetes 2021; 12(11): 1812-1817
- URL: https://www.wjgnet.com/1948-9358/full/v12/i11/1812.htm
- DOI: https://dx.doi.org/10.4239/wjd.v12.i11.1812