Copyright ©The Author(s) 2021.
World J Diabetes. Nov 15, 2021; 12(11): 1812-1817
Published online Nov 15, 2021. doi: 10.4239/wjd.v12.i11.1812
Table 1 Summary of the selected studies on the long-term effect of metformin on the anthropometry and metabolic parameters of the offspring
Follow-up timing
Main outcomes
Rowan et al[11]2011Australia and New Zealand 2 yrMetformin exposed children had (1) Larger mid-upper arm circumferences, biceps and subscapular skinfold thickness; and (2) Total fat mass and percentage body fat were similar to insulin group
Rowan et al[13]2018Australia and New Zealand7 yr and 9 yr in Adelaide and Auckland cohort respectivelyNo difference in the metformin-exposed children and insulin-treated mothers in Adelaide cohort. In Auckland cohort: (1) Metformin-exposed children had larger weight, arm and waist circumferences, and waist: Height ratio; (2) Similar body fat percentage between two treatment groups; and (3) Visceral adipose tissue, abdominal subcutaneous adipose tissue and liver fat were similar in metformin exposed group in comparison to insulin treatment
Ijäs et al[14]2014Finland mo(1) Children exposed to metformin were significantly heavier at the age of 12 mo; and (2) Metformin exposed offspring were taller and heavier at the age of 18 mo
Landi et al[15]2019New Zealand4 yrNo significant differences in weight, weight for height, or body mass index in children of insulin versus metformin exposed mothers
Paul et al[16]2020India 9 yr(1) No difference in weight, body mass index, waist circumference, body fat percentages in between metformin and glibenclamide exposed children; and (2) Similar metabolic profile between two groups except mild elevation of serum triglyceride in the metformin group