Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Nov 15, 2021; 12(11): 1812-1817
Published online Nov 15, 2021. doi: 10.4239/wjd.v12.i11.1812
Long-term effects of metformin use in gestational diabetes mellitus on offspring health
Ayan Roy, Jayaprakash Sahoo
Ayan Roy, Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Jodhpur 342005, Rajasthan, India
Jayaprakash Sahoo, Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry 605006, India
Author contributions: Sahoo J conceptualized the work; Roy A wrote the first draft; Roy A and Sahoo J edited the final draft with critical inputs; Both authors have read and approved the final version of the manuscript.
Conflict-of-interest statement: All authors have no conflicts of interest to report.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jayaprakash Sahoo, MBBS, MD, DM, Additional Professor, Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education and Research, Room No. 5444, 4th floor, Puducherry 605006, India. jppgi@yahoo.com
Received: March 21, 2021
Peer-review started: March 21, 2021
First decision: May 3, 2021
Revised: May 15, 2021
Accepted: October 3, 2021
Article in press: October 3, 2021
Published online: November 15, 2021
Core Tip

Core Tip: The use of metformin in mild-to-moderate gestational diabetes mellitus may confer certain advantages. Since metformin reaches almost a similar serum level in the fetus, it is likely to influence the fetal metabolic environment. Limited long-term data suggest that metformin-exposed children have mild adverse anthropometric profiles. However, the clinical significance and effect on cardiometabolic health have yet to be determined.