Systematic Reviews
Copyright ©The Author(s) 2020.
World J Diabetes. Mar 15, 2020; 11(3): 78-89
Published online Mar 15, 2020. doi: 10.4239/wjd.v11.i3.78
Table 2 Objective of the study, findings and outcome data
Quilici et al[21]Cross-sectional studyPrevalence of amputation was 42% due to the previous use of antimicrobials. Risk of amputation was 26% for patients who had less compliant with the diabetes treatmentHighlight factors for the management patients with diabetic foot infection
Commons et al[26]Prospective study was conducted among patients with diabetic foot infections, enrolled in Royal Darwin Hospital, were selected. The relation with Pseudomonas aeruginosa and methicillin resistant Staphylococcus aureus was also determinedP. aeruginosa and Methicillin resistant S. aureus infections were cured by long-term courses of antibiotics and increased hospital stayPrevalence of diabetic foot ulcer is directly and significantly related to the best bed days
Barwell et al[28]A literature review was conductedAntibiotic and antimicrobial resistance of Gram positive organisms occurred as a main challenge in the treatment of diabetic foot infectionProvides guideline as empirical evidence to support clinicians
Roth-Albin et al[24]Retrospective cohort study35 out of 40 patients were healed in 52 weeks. 7.1% underwent amputation and 8.9% died before receiving any kind of treatmentHealing rates significantly improved by proper and continued care
Fitzgerald et al[30]Retrospective exploratory studyDiabetes and Cardiovascular disease/peripheral-vascular disease was identified in 2 and 6 patients, respectively. 28 patients had foot ulcers and RA. Inflicted patients were treated with antirheumatic drugs and steroidsInaccurate diagnosis of ulcer infection leads to failure of microbiological analysis
Kathirvel et al[22]150 patients’ clinical examination, clinical history and microbiological profile were prospectively examined99 patients were isolated from MDRO. MDRO risk factors include; previous antibiotic usage, retinopathy, polymicrobial culture, presence of ulcer, antibiotic usage, ulcer size, history of amputation, peripheral vascular disease, neuropathy, and necrotic ulcerMDRO prevalence was high among diabetic patients with foot ulcers
Xie et al[16]Retrospective study was conducted using 207 bacteria from diabetic foot infections. Microbial and clinical information was also collectedGram negative bacteria were found to be more as compared to gram positive bacteria with, Staphylococcus and Enterobacteriaceae to be the most dominantThe antibiotic sensitivity and bacterial profile of diabetic foot ulcers varied with their types and grades
Dwedar et al[41]80 patients with diabetic foot infections were prospectively studiedGram negative bacteria were more common. Vancomycin was found to be the best against gram-positive bacteria; whereas, colistin, imipenem and amikacin were effective against gram-negative bacteriaKnowledge regarding antibiotic sensitivity is required for future treatment of diabetic foot ulcers
Abbas et al[45]Non-systematic researchAntibiotic therapy is necessary for several clinically infected woundsAntibiotic therapies should be used for treatment
Oliveira et al[46]Descriptive, retrospective and epidemiological study was used65% of cases suffered amputations. Staphylococci was the most common bacteria type. Three patients were found to be enterobacteria and second was, StaphylococciClindamycin and cephalexin were most resistant to bacteria