Systematic Reviews
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Mar 15, 2020; 11(3): 78-89
Published online Mar 15, 2020. doi: 10.4239/wjd.v11.i3.78
Prevalence and interrelationships of foot ulcer, risk-factors and antibiotic resistance in foot ulcers in diabetic populations: A systematic review and meta-analysis
Mohammad Zubair
Mohammad Zubair, Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, Tabuk 71491, Saudi Arabia
Author contributions: Zubair M design the concept, performed the research, analysis and wrote the manuscript.
Conflict-of-interest statement: Author have no conflict of interest related to the manuscript.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Corresponding author: Mohammad Zubair, PhD, Assistant Professor, Department of Medical Microbiology, Faculty of Medicine, University of Tabuk, PO Box 71491, Tabuk 71491, Saudi Arabia.
Received: August 21, 2019
Peer-review started: August 21, 2019
First decision: October 13, 2019
Revised: November 21, 2019
Accepted: January 8, 2020
Article in press: January 8, 2020
Published online: March 15, 2020
Research background

Globally, the occurrence of diabetic foot ulceration (DFU) reported as a significant health concern which calls for early prevention and diagnosis.

Research motivation

This study would assist in setting out relevant guidelines for reducing the incidence of DFU and overcome the resistance among patients for its treatment.

Research objectives

The main objectives were to examine the interrelationships between foot ulcers, risk factors, and antibiotic resistance among diabetic patients having ulcers in their foot.

Research methods

A systematic and meta-analysis method is adopted for providing comprehensive insights on the DFU prevalence, risk factors as well as its resistance.

Research results

The research findings showed an increased prevalence of gram-negative bacteria among the DFU cases.

Research conclusions

The review concludes hypertension and neuropathy as the major risk factors among DFU patients.

Research perspectives

The review highlights that antimicrobial susceptibility can be considered for attaining better treatment outcomes.