Effectiveness of drug interventions in nonalcoholic fatty liver disease: A network meta-analysis

Figure 1 Network of evidence of included studies. GLP-1: Glucagon-like peptide-1 receptor agonists; TZD: Thiazolidinediones; MET: Metformin; SGLT2: Sodium glucose cotransporter-2 inhibitors; PLA: Placebo; HFC: Hepatic fat content; NAS: Nonalcoholic fatty liver disease activity score; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Serum γ-glutamyl transferase.

Figure 2 Literature screening flowchart. RCTs: Randomized controlled trials.

Figure 3 Relative effects of various outcomes. Treatments are ranked according to their chance of being the best treatment. “High” means the highest probability of being the best treatment, and “Low” means the lowest probability of being the best treatment. Numbers in the crimson boxes are the SUCRA (surface under the cumulative ranking curve) values, which represent the level of treatment. The higher the value, the greater the probability of being the best intervention. Significant pairwise comparisons are highlighted in bold and underlined. GLP-1: Glucagon-like peptide-1 receptor agonists; TZDs: Thiazolidinediones; Met: Metformin; SGLT2: Sodium glucose cotransporter-2 inhibitors; Pla: Placebo; HFC: Hepatic fat content; NAS: Nonalcoholic fatty liver disease activity score; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Serum γ-glutamyl transferase.