Published online Dec 15, 2018. doi: 10.4239/wjd.v9.i12.230
Peer-review started: August 27, 2018
First decision: October 5, 2018
Revised: October 15, 2018
Accepted: November 26, 2018
Article in press: November 27, 2018
Published online: December 15, 2018
Core tip: What is the most effective combination of drugs and exercise for the treatment of type 2 diabetes? It has become increasingly important for clinicians to prescribe drugs that reduce cardiovascular disease and mortality in addition to their glucose-lowering effects. This review summarized the current literature investigating the effect of glucose-lowering agents on cardiorespiratory fitness. Thiazolidinediones, sodium–glucose cotransporter 2 inhibitors, and glucagon-like peptide-l receptor agonists have the potential to improve cardiorespiratory fitness; however, further research will be needed to confirm.