Basic Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jan 15, 2018; 9(1): 25-32
Published online Jan 15, 2018. doi: 10.4239/wjd.v9.i1.25
Short-term effects of obestatin on hexose uptake and triacylglycerol breakdown in human subcutaneous adipocytes
Christian Carpéné, Francisco Les, David Estève, Jean Galitzky
Christian Carpéné, David Estève, Jean Galitzky, Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale, Université Paul Sabatier, Toulouse 31432, France
Francisco Les, Department of Pharmacy, Faculty of Health Sciences, Universidad San Jorge, Villanueva de Gállego 50830, Spain
Author contributions: Carpéné C and Galitzky J substantially contributed to the conception, design of the study and drafted the manuscript; Carpéné C, Les F and Estève D worked in data acquisition and orientated their analysis after bibliographical research; and all authors approved the submitted version of the paper after careful perusal.
Supported by Erasmus plus Traineeship program.
Institutional review board statement: The study was reviewed by the Institutional Review Board of Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France. The study was approved by the local Ethics Committe: “Comité de Protection des Personnes Sud Ouest et Outre mer II”.
Conflict-of-interest statement: All authors declare that they do not have any potential conflict of interest in relation to this article.
Data sharing statement: No supplementary data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
Correspondence to: Dr. Christian Carpéné, Institut des Maladies Métaboliques et Cardiovasculaires, Institut National de la Santé et de la Recherche Médicale, Université de Toulouse, CHU Rangueil, UPS, Toulouse 31432, France.
Telephone: +33-5-61325640
Received: February 7, 2017
Peer-review started: February 12, 2017
First decision: May 17, 2017
Revised: November 17, 2017
Accepted: December 4, 2017
Article in press: December 4, 2017
Published online: January 15, 2018
Core Tip

Core tip: We have compared in adipocytes the well-known glucose uptake stimulation and lipolysis inhibition induced by insulin to the effects of obestatin, a gut peptide derived from ghrelin gene recently proposed to act on fat cells. Obestatin was much less efficient than insulin in adipocytes from human abdominal subcutaneous adipose tissue. Indeed, obestatin weakly activated hexose transport while it could not reproduce the antilipolytic effect of insulin at any tested concentration. We therefore propose that obestatin does not rapidly modulate lipogenesis and lipolysis and that its contribution to energy homeostasis depends on actions other than a direct control of adipocyte metabolism.