Published online Oct 15, 2016. doi: 10.4239/wjd.v7.i18.441
Peer-review started: February 14, 2016
First decision: March 23, 2016
Revised: July 28, 2016
Accepted: August 6, 2016
Article in press: August 10, 2016
Published online: October 15, 2016
Core tip: The incidence of metabolic syndrome (MetS) is on the rise globally. This will have a negative impact on cardiovascular outcome. Whereas most of the anti-hyperglycemic agents have neutral or negative effects on components of MetS, glucagon-like peptide-1 receptor agonists drugs favorably address all components of MetS. By doing so, they may have a cardio protective role. We have reviewed recent literature to give an updated account on the topic. Results from recently concluded clinical trials suggest that some of the molecules in this class may have favorable effects on cardiovascular outcome.