Published online Jul 10, 2015. doi: 10.4239/wjd.v6.i7.961
Peer-review started: August 30, 2014
First decision: October 28, 2014
Revised: November 20, 2014
Accepted: March 30, 2015
Article in press: April 2, 2015
Published online: July 10, 2015
Core tip: Diabetes mellitus (DM) is a major risk factor of peripheral artery disease (PAD), leading to increased morbidity and mortality as well as an accelerated disease course. As such, a more thorough understanding of the multi-factorial mechanisms underlying disease etiology for both DM and PAD is justified. This review provides clinical insight into the current state of research in the pathophysiology of PAD in diabetic patients, as well as highlights the progress of endovascular interventions for PAD, with a focus on techniques that have shown promise for treatment of critical lower limb ischemia.