Basic Study
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2015; 6(4): 662-672
Published online May 15, 2015. doi: 10.4239/wjd.v6.i4.662
Advanced glycation end-product expression is upregulated in the gastrointestinal tract of type 2 diabetic rats
Peng-Min Chen, Hans Gregersen, Jing-Bo Zhao
Peng-Min Chen, Department of Molecular Biology, Institute of Clinical Medicine, China-Japan Friendship Hospital, Beijing 100029, China
Hans Gregersen, GIOME Center, College of Bioengineering, Chongqing University, Chongqing 400045, China
Jing-Bo Zhao, Institute of Clinical Medicine, Aarhus University, Aarhus N 8200, Denmark
Author contributions: Gregersen H and Zhao JB designed the research; Chen PM and Zhao JB performed the research and analyzed the data; Chen PM and Zhao JB wrote the paper; Gregersen H revised the paper.
Supported by Karen Elise Jensens Foundation.
Ethics approval: Ethics of the study was approved by the Danish Committee for Animal Experimentation. The license number is 2008/561-1530.
Institutional animal care and use committee: All procedures involving animals were reviewed and approved by the Danish Committee for Animal Experimentation. The license number is 2008/561-1530. Animals in poor clinical condition were euthanized and excluded from the study. The rats were euthanized with CO2 inspiration during the anesthesia. The animals were acclimatized to laboratory conditions (22 °C, 12 h/12 h light/dark, 50% humidity, ad libitum access to food and water) for 2 wk prior to experimentation. The animal protocol was designed to minimize pain or discomfort to the animals.
Conflict-of-interest: We declare that we have no proprietary, financial, professional or other personal interest of any product, service and/or company that could be construed as influencing the position presented in, or the review of, the manuscript entitle “Advanced Glycation End-Product expression is upregulated in the Gastrointestinal Tract of Type 2 Diabetic Rats”.
Data sharing: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Hans Gregersen, Professor, GIOME Center, College of Bioengineering, Chongqing University, 83 Shabei Road, Chongqing 400045, China. hag@giome.org
Telephone: +86-186-00556254
Received: August 6, 2014
Peer-review started: August 7, 2014
First decision: October 28, 2014
Revised: March 4, 2015
Accepted: March 16, 2015
Article in press: March 18, 2015
Published online: May 15, 2015
Core Tip

Core tip: Changes in advanced glycation end products (AGEs) and their receptor (RAGE) expression in the gastrointestinal (GI) tract in type 2 diabetic rats were studied. The AGE and RAGE were widely distributed in epithelial cells of all segments as well as in striated muscle cells in the esophagus. RAGE also distributed in neurons in all segments. Up-regulated AGE and RAGE expression was found in the GI tract of GK diabetic rats. The altered AGE and RAGE may be a contributing factor for GI dysfunction in type 2 diabetic patients.