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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Apr 15, 2015; 6(3): 423-431
Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.423
Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.423
Endothelial and platelet markers in diabetes mellitus type 2
Peter Kubisz, Lucia Stančiaková, Ján Staško, National Centre of Haemostasis and Thrombosis, Clinic of Haematology and Transfusiology, Comenius University in Bratislava, Jessenius Faculty of Medicine and University Hospital in Martin, 03659 Martin, Slovak Republic
Peter Galajda, Marián Mokáň, Department of Internal Medicine I, Comenius University in Bratislava, Jessenius Faculty of Medicine and University Hospital in Martin, 03659 Martin, Slovak Republic
Author contributions: Kubisz P, Staško J and Stančiaková L wrote the paper; Kubisz P, Staško J, Galajda P and Mokáň M designed and performed the research with obtaining the results, on the basis of which the review was partially written; all authors had read and approved the final version of the manuscript.
Supported by Projects CEPV I (ITMS 26220120016), CEVYPET (ITMS 26220120053), APVV 0222-11 and Vega 1/0016/12.
Conflict-of-interest: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Peter Kubisz, MD, DSc, Professor, National Centre of Haemostasis and Thrombosis, Clinic of Haematology and Transfusiology, Comenius University in Bratislava, Jessenius Faculty of Medicine and University Hospital in Martin, Kollarova Str. N. 2, 03659 Martin, Slovak Republic. kubisz@jfmed.uniba.sk
Telephone: +421-43-4203232 Fax: +421-43-4132061
Received: September 1, 2014
Peer-review started: September 1, 2014
First decision: November 27, 2014
Revised: January 12, 2015
Accepted: January 30, 2015
Article in press: February 2, 2015
Published online: April 15, 2015
Peer-review started: September 1, 2014
First decision: November 27, 2014
Revised: January 12, 2015
Accepted: January 30, 2015
Article in press: February 2, 2015
Published online: April 15, 2015
Core Tip
Core tip: Number of diabetics increases, what leads to worldwide increasing diabetes-associated vascular events. Moreover, diabetes mellitus type 2 is the most common acquired thrombophilia. Therefore, to prevent life-threatening vascular complications in subjects with diabetes, mechanisms and markers of endothelial and platelet dysfunction have been investigated. In order to contribute to better management of discussed patients and to increase knowledge about their origin, in this article we tried to summarize the pathogenesis of endothelial and platelet dysfunction and to characterize possible predictors of abnormalities of endothelium and platelets, as well as methods of their detection.