Published online Apr 15, 2015. doi: 10.4239/wjd.v6.i3.403
Peer-review started: August 30, 2014
First decision: December 17, 2014
Revised: January 10, 2015
Accepted: January 30, 2015
Article in press: February 2, 2015
Published online: April 15, 2015
Core tip: Imbalances in the intestinal microbiota (dysbiosis) have been linked to diseases, including diabetes. In short- and medium-term trials conducted in patients with type 2 diabetes mellitus (T2DM), the Ma-Pi 2 diet, which is rich in carbohydrates, whole grains and vegetables, with no animal fat or protein or added sugar, has been found to significantly improve indicators of metabolic control, including fasting blood glucose, glycosylated hemoglobin, the serum lipid profile, body mass index, body weight and blood pressure. The diet may also alter the gut microbiota composition. Hence, the Ma-Pi 2 diet could be considered a valid additional short- to medium-term treatment for T2DM.