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©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Aug 25, 2015; 6(10): 1168-1178
Published online Aug 25, 2015. doi: 10.4239/wjd.v6.i10.1168
Published online Aug 25, 2015. doi: 10.4239/wjd.v6.i10.1168
Simvastatin, atorvastatin, and pravastatin equally improve the hemodynamic status of diabetic rats
María J Crespo, Departments of Physiology and Anesthesiology, University of Puerto Rico-School of Medicine, San Juan, PR 00936-5067, United States
María J Crespo, José Quidgley, Departments of Physiology, University of Puerto Rico-School of Medicine, San Juan, PR 00936-5067, United States
Author contributions: Crespo MJ and Quigley J contributed equally to this work.
Supported by MBRS-RISE, No. R25-GM061838; and RCMI, No. G12-RR03051.
Institutional review board statement: Ethics of the study was approved by the Institutional Animal Care and Use Committee of the University of Puerto Rico-Medical Sciences Campus. The protocol number is 2590108.
Institutional animal care and use committee statement: Institutional animal care and use committee: All experiments were approved by the Institutional Animal Care and Use Committee of the University of Puerto Rico-Medical Sciences Campus (Protocol number: 2590108), and adhered to guidelines established by the National Institutes of Health and the American Veterinary Medical Association.
Conflict-of-interest statement: No conflict of interest to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. María J Crespo, Departments of Physiology and Anesthesiology, University of Puerto Rico-School of Medicine, GPO Box 365067, San Juan, PR 00936-5067, United States. maria.crespo3@upr.edu
Telephone: +1-787-7530120 Fax: +1-787-7530120
Received: April 25, 2015
Peer-review started: April 28, 2015
First decision: June 9, 2015
Revised: July 28, 2015
Accepted: August 16, 2015
Article in press: August 17, 2015
Published online: August 25, 2015
Peer-review started: April 28, 2015
First decision: June 9, 2015
Revised: July 28, 2015
Accepted: August 16, 2015
Article in press: August 17, 2015
Published online: August 25, 2015
Core Tip
Core tip: Despite evidence that statins are useful therapeutic tools in treating diabetes, questions remain as to whether their effects are drug-specific or class-dependent, what mechanisms underlie these effects, and which statin is the most appropriate. We found that atorvastatin, simvastatin, and pravastatin are equally effective in improving cardiovascular performance in Type 1 diabetic rats, and that the observed benefits are likely to be secondary to the reduction of oxidative stress by these drugs.