Diagnosis of hepatic glycogenosis in poorly controlled type 1 diabetes mellitus

doi:10.4239/wjd.v5.i6.882

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Dec 15, 2014; 5(6): 882-888
Published online Dec 15, 2014. doi: 10.4239/wjd.v5.i6.882

Diagnosis of hepatic glycogenosis in poorly controlled type 1 diabetes mellitus

Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi

Stefania Giordano, Antonio Martocchia, Lavinia Toussan, Manuela Stefanelli, Francesca Pastore, Antonio Devito, Marcello G Risicato, Luigi Ruco, Paolo Falaschi, Geriatric Unit, “Sapienza” University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, 00189 Rome, Italy

Author contributions: All authors contributed to this manuscript.

Correspondence to: Stefania Giordano, MD, Geriatric Unit, “Sapienza” University of Rome, Faculty of Medicine and Psychology, S. Andrea Hospital, Via di Grottarossa 1035/39, 00189 Rome, Italy. s.giordano87@yahoo.it

Telephone: +39-06-33775467 Fax: +39-06-33775401

Received: August 12, 2014
Revised: October 2, 2014
Accepted: October 23, 2014
Published online: December 15, 2014

Core Tip

Core tip: This review contain an extensive revision of the case reports described in literature; in particular glycemic control (elevation of glycated hemoglobin, HbA1c levels, presence of ketoacidosis and insulin dosage), imaging studies and bioptic findings are summarized and discussed. The pathophysiological mechanisms behind the accumulation of glycogen in hepatocytes in patient with poorly controlled type 1 diabetes mellitus are described in detail.