Review
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World J Diabetes. Dec 15, 2014; 5(6): 809-816
Published online Dec 15, 2014. doi: 10.4239/wjd.v5.i6.809
Association of genetic variants with diabetic nephropathy
Saliha Rizvi, Syed Tasleem Raza, Farzana Mahdi
Saliha Rizvi, Syed Tasleem Raza, Farzana Mahdi, Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Lucknow 226003, India
Author contributions: Rizvi S, Raza ST and Mahdi F solely contributed to this paper.
Correspondence to: Syed Tasleem Raza, PhD, Department of Biochemistry, Era’s Lucknow Medical College and Hospital, Hardoi Road, Lucknow 226003, India. tasleem24@gmail.com
Telephone: +91-522-2408122 Fax: +91-522-2407824
Received: June 5, 2014
Revised: July 9, 2014
Accepted: September 6, 2014
Published online: December 15, 2014
Core Tip

Core tip: Diabetic nephropathy is actually the most common cause of kidney failure. It is now a scientifically proven fact that there is a strong association between an individual’s genetic makeup in his predisposition to diabetic nephropathy. Multiple genes are involved in pathogenesis of diabetic nephropathy, with several allelic polymorphisms having demonstrable effects in the development and progression of the disease thus contributing to the overall risk. These gene polymorphism studies are thus conducted to identify at-risk patients and design therapeutic strategies to prevent the outcome of such complication in his later future. This review discusses about the various gene variants found till date to be associated with diabetic nephropathy.