Evidence-Based Medicine
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Oct 15, 2014; 5(5): 711-716
Published online Oct 15, 2014. doi: 10.4239/wjd.v5.i5.711
HLA alleles may serve as a tool to discriminate atypical type 2 diabetic patients
Mariana Fernández, Matías Fabregat, Gerardo Javiel, Adriana Mimbacas
Mariana Fernández, Matías Fabregat, Gerardo Javiel, Adriana Mimbacas, Biodiversity and Genetic Department, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, CP 11600, Uruguay
Gerardo Javiel, Unit of Diabetes Hospital Pasteur, ASSE-Ministry of Public Health, Montevideo, CP 11400, Uruguay
Gerardo Javiel, Diabetologyc Service of Private Health Center, Centro de Asistencia del Sindicato Médico del Uruguay (CASMU), Montevideo, CP 11600, Uruguay
Author contributions: Fernández M and Fabregat M performed the experiment and were also involved in editing the manuscript; Javiel G and Mimbacas A co-ordinated and provided the collection of all human material in addition to providing financial support; Fernández M and Mimbacas A designed the study.
Correspondence to: Adriana Mimbacas, PhD, Biodiversity and Genetic Department, Instituto de Investigaciones Biológicas Clemente Estable, Avenida Italia 3318, Montevideo, CP 11600, Uruguay. amimbacas@iibce.edu.uy
Telephone: +598-2-4861417 Fax: +598-2-4875548
Received: February 27, 2014
Revised: May 1, 2014
Accepted: July 18, 2014
Published online: October 15, 2014
Core Tip

Core tip: There are evidences that exists a lot of patients who were diagnosed as type 2 diabetics but present difficult management, don’t have good responses to treatment and don’t achieve the metabolic goals. We include the study of human leukocyte antigen markers typically associated whit type 1 diabetes to characterize these patients. This paper provides information about the possibility of incorporate a standardized molecular diagnosis in the clinical practice to identify complex or atypical type 2 diabetic patient.