Review
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World J Diabetes. Aug 15, 2014; 5(4): 527-535
Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.527
Domino effect of hypomagnesemia on the innate immunity of Crohn’s disease patients
Saleh A Naser, Almatmed Abdelsalam, Saisathya Thanigachalam, Abed S Naser, Karel Alcedo
Saleh A Naser, Almatmed Abdelsalam, Saisathya Thanigachalam, Abed S Naser, Karel Alcedo, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, FL 32816, United States
Author contributions: All authors contributed equally to the preparation and revision of the manuscript.
Correspondence to: Saleh A Naser, PhD, Professor, Graduate Coordinator, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Building 20, BMS 136, 4110 Libra Drive, Orlando, FL 32816, United States. saleh.naser@ucf.edu
Telephone: +1-407-8230955 Fax: +1-407-8230956
Received: May 15, 2014
Revised: May 28, 2014
Accepted: May 29, 2014
Published online: August 15, 2014
Core Tip

Core tip: Magnesium is an essential trace mineral, which plays key role as an immunomodulator in many pathways leading to homeostasis. Hypomagnesemia is common in patients with Crohn’s disease (CD) and may be the cause of upregulation of pro-inflammatory factors leading to aggravating symptoms. Therefore, understanding the role of magnesium in maintaining a healthy immune response is important for effective treatment of patients with CD.