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World J Diabetes. Aug 15, 2014; 5(4): 505-510
Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.505
Distinct clinical and laboratory characteristics of latent autoimmune diabetes in adults in relation to type 1 and type 2 diabetes mellitus
Elena Pipi, Marietta Marketou, Alexandra Tsirogianni
Elena Pipi, Marietta Marketou, Alexandra Tsirogianni, Department of Immunology-Histocompatibility, Evangelismos General Hospital, Athens 10676, Greece
Elena Pipi, Department of Dermatology, University of Lübeck, Lübeck 23539, Germany
Author contributions: Pipi E and Marketou M drafted the manuscript; Tsirogianni A critically revised the draft.
Correspondence to: Dr. Alexandra Tsirogianni, MD, PhD, Director of Immunology-Histocompatibility Department, Evangelismos General Hospital, Ipsilantou 45-47, Athens 10676, Greece. alextsir@gmail.com
Telephone: +30-21-32043075 Fax: +30-21-32043181
Received: November 27, 2013
Revised: March 14, 2014
Accepted: June 18, 2014
Published online: August 15, 2014
Core Tip

Core tip: A unique combination of, immunological, clinical and metabolic characteristics has been identified in latent autoimmune diabetes in adults (LADA) patients. Even so, the current definition of LADA fails to capture in one snapshot insulin resistance and autoimmunity, this very special pathognomonic characteristic of LADA. Addressing this dual facet of LADA would undoubtedly provide insight into disease pathogenesis and help in the immediate identification and prompt insulin therapy.