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World J Diabetes. Aug 15, 2014; 5(4): 493-504
Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.493
Published online Aug 15, 2014. doi: 10.4239/wjd.v5.i4.493
Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus
Monisha Banerjee, Madhukar Saxena, Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow 226007, India
Author contributions: Both the authors contributed equally to the manuscript.
Supported by Agencies viz Department of Biotechnology (DBT), Indian Council of Medical Research (ICMR), Department of Science and Technology (DST) and Centre of Excellence (COE), UP Government, India for generous grants to our laboratory for diabetes research
Correspondence to: Monisha Banerjee, Associate Professor, Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, University Road, Lucknow 226007, India. banerjee_monisha30@rediffmail.com
Telephone: +91-983-9500439
Received: November 28, 2013
Revised: May 26, 2014
Accepted: June 14, 2014
Published online: August 15, 2014
Revised: May 26, 2014
Accepted: June 14, 2014
Published online: August 15, 2014
Core Tip
Core tip: Diabetes is the third most widespread disease after heart disease and cancer. Cytokines are mediators of inflammation, namely interleukins (IL)-1β, -1Ra, -18, -4, -6, -10, tumor necrosis factor-α and adiponectin, which cause immune responses in disease pathogenesis, including type 2 diabetes. In the present study, the association of cytokine gene polymorphisms in different ethnic populations is reviewed. Such single nucleotide polymorphism analyses and association studies in different populations will benefit individuals belonging to a particular group.