Published online Feb 15, 2014. doi: 10.4239/wjd.v5.i1.69
Revised: October 21, 2013
Accepted: January 15, 2014
Published online: February 15, 2014
Core tip: To start insulin therapy in insulin naïve type 2 diabetes patients, a long-acting basal insulin, such as insulin glargine, is added once a day. The majority of algorithms determine insulin titration according to fasting plasma glucose levels, but the dosage differs at the initial dose, frequency and speed of adjustments. It is difficult to compare the different algorithms employed in trials with populations of different socio-economic strata and variable access to educational materials. Here, we compared the safety of different titration algorithms in a population that was homogeneous in terms of socio-economic strata and with the same degree of education in diabetes.