Published online Feb 15, 2014. doi: 10.4239/wjd.v5.i1.52
Revised: December 20, 2013
Accepted: January 13, 2014
Published online: February 15, 2014
Core tip: Insulin resistance is one of the pathological features in patients with hepatitis C virus (HCV) infection and often leads to development of type II diabetes. Recent evidence indicates that HCV associated insulin resistance may result in hepatic fibrosis, steatosis, hepatocellular carcinoma and resistance to anti-viral treatment. In this review, we summarize the available information on how HCV infection interferes with insulin signaling pathways.