Published online Dec 15, 2013. doi: 10.4239/wjd.v4.i6.245
Revised: November 2, 2013
Accepted: November 15, 2013
Published online: December 15, 2013
Core tip: Diagnostic tests are useful to predict onset, progression and response to therapeutic interventions in diabetic nephropathy (DN). Renal biopsies help to classify renal diseases in three major groups associated with different prognostic features: diabetic nephropathy, non-diabetic nephropathy (NDRD), and a superimposed non-diabetic condition on underlying DN. Pathological renal damage is hard to predict only with clinical and laboratory findings. In patients with a higher degree of suspicion for NDRD, it is granted the need of a renal biopsy. For this reason, more studies are required to assess the routine use of kidney biopsies as a gold standard for diagnosis of diabetic nephropathy.