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Zoghoul S, Obeidat M, Abdallah E, Al-Hashemi A, Shalaby R, Al-Hashimi I, El-Menyar A, Al-Thani H, Omar A, Barah A. Angiosome-targeted vs non-targeted endovascular revascularization in diabetic foot ischemia: A retrospective cohort study. World J Diabetes 2026; 17(11): 124667 [DOI: 10.4239/wjd.124667]
World J Diabetes. Nov 15, 2026; 17(11): 124667 Published online Nov 15, 2026. doi: 10.4239/wjd.124667
Angiosome-targeted vs non-targeted endovascular revascularization in diabetic foot ischemia: A retrospective cohort study
Sohaib Zoghoul, Mohammad Obeidat, Elhassan Abdallah, Abdullah Al-Hashemi, Rana Shalaby, Israa Al-Hashimi, Ayman El-Menyar, Hassan Al-Thani, Ahmed Omar, Ali Barah
Sohaib Zoghoul, Mohammad Obeidat, Elhassan Abdallah, Abdullah Al-Hashemi, Rana Shalaby, Israa Al-Hashimi, Ahmed Omar, Ali Barah, Department of Radiology, Hamad Medical Corporation, Doha 3050, Qatar
Ayman El-Menyar, Hassan Al-Thani, Department of Surgery, Hamad Medical Corporation, Doha 3050, Qatar
Ayman El-Menyar, Department of Clinical Medicine, Weill Cornell Medicine, Doha 24144, Qatar
Co-corresponding authors: Ayman El-Menyar and Ali Barah.
Author contributions: Manuscript editing and reviewing were performed by El-Menyar A, Al-Thani H, Omar A, and Barah A; data curation and interpretation were performed by Zoghoul S, Obeidat M, Abdallah E, Al-Hashemi A, Shalaby R, and Al-Hashimi I; conceptualization and methods were performed by Omar A and Barah A; and analysis and writing were performed by Zoghoul S, El-Menyar A, and Barah A. El-Menyar A and Barah A contributed equally to this study as co-corresponding authors. All authors contributed substantially to the study and read and agreed to the published version of this manuscript.
AI contribution statement: AI was not used.
Institutional review board statement: This study was approved by the Research Ethics Committee at Medical Research Center, Hamad Medical Corporation, Doha, Qatar (Approval No. MRC-01-25-287).
Informed consent statement: There was no direct contact with participants, and data were collected anonymously and retrospectively. Therefore, patient informed consent was not required.
Conflict-of-interest statement: The authors declare no conflict of interest.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Data sharing statement: Data will be available upon reasonable request and after approval by the Medical Research Center of Hamad Medical Corporation and signing of a data-sharing agreement form.
Corresponding author: Ayman El-Menyar, MD, Department of Surgery, Hamad Medical Corporation, Al-Rayyan Street, Doha 3050, Qatar. aymanco65@yahoo.com
Received: June 23, 2026 Revised: July 17, 2026 Accepted: September 18, 2026 Published online: November 15, 2026 Processing time: 137 Days and 15.6 Hours
Core Tip
Core Tip: In a country with a high prevalence of diabetes mellitus, this study examined patients with diabetic foot ischemia undergoing endovascular revascularization. Angiosome-targeted revascularization showed no statistically significant association with wound healing, major amputation, or limb salvage compared with non-targeted or combined revascularization. Multivariable logistic regression identified wound severity (Wagner grade), patient age, and follow-up duration as the dominant independent predictors of wound healing, while procedure group was not an independent predictor of either primary outcome. These findings were consistent across all prespecified subgroup and sensitivity analyses. Prospective multicenter studies are warranted.
