Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2025; 16(7): 108262
Published online Jul 15, 2025. doi: 10.4239/wjd.v16.i7.108262
Prognostic value of microRNA-495-3p, adiponectin, and cardiometabolic index in type 2 diabetic nephropathy
Xu-Chun Xu, He-Jing Fang, Hua-Ying Huang
Xu-Chun Xu, He-Jing Fang, Department of Nephrology, Jinhua Municipal Central Hospital, Jinhua 321000, Zhejiang Province, China
Hua-Ying Huang, Department of Endocrine Metabolism, Jinhua Municipal Central Hospital, Jinhua 321000, Zhejiang Province, China
Author contributions: Xu XC and Fang HJ designed the study and performed the experiments; Huang HY collected the data; Xu XC analyzed the data and prepared the manuscript; All authors read and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethics Committee of Jinhua Municipal Central Hospital.
Informed consent statement: Signed written informed consents were obtained from the patients and/or guardians.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xu-Chun Xu, MD, Doctor, Department of Nephrology, Jinhua Municipal Central Hospital, No. 365 Renmin East Road, Jinhua 321000, Zhejiang Province, China. xuchunxu099@163.com
Received: April 15, 2025
Revised: April 26, 2025
Accepted: May 29, 2025
Published online: July 15, 2025
Processing time: 90 Days and 23.3 Hours
Core Tip

Core Tip: This study identifies serum microRNA-495-3p (miR-495-3p), adiponectin (ADPN), and cardiometabolic index (CMI) as novel biomarkers for predicting poor prognosis in type 2 diabetic nephropathy (T2DN). Lower miR-495-3p and higher ADPN/CMI levels correlate with worse renal outcomes, offering clinical utility for risk stratification. Multivariate analysis confirms their independent predictive value alongside liver/kidney function markers. These findings highlight miR-495-3p’s potential as a key prognostic indicator, advancing personalized management strategies for T2DN.