Retrospective Cohort Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2025; 16(7): 104306
Published online Jul 15, 2025. doi: 10.4239/wjd.v16.i7.104306
Predictive ability of lipid indices for large-for-gestational-age infants in pregnant females with gestational diabetes mellitus
Lan-Lan Xiang, Jie Feng, Shu-Yu Li, Yi-Tian Zhu, Ya-Jun Chen, Tian-Ying Zhong, Ye-Fei Zhu, Yu Zeng
Lan-Lan Xiang, Shu-Yu Li, Yi-Tian Zhu, Ya-Jun Chen, Tian-Ying Zhong, Yu Zeng, Department of Clinical Laboratory, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, Nanjing 210002, Jiangsu Province, China
Jie Feng, Key Laboratory, NHC Key Laboratory of Contraceptives Vigilance and Fertility Surveillance, Nanjing 210000, Jiangsu Province, China
Jie Feng, Key Laboratory, Jiangsu Provincial Medical Key Laboratory of Fertility Protection and Health Technology Assessment, Nanjing 210000, Jiangsu Province, China
Jie Feng, Research Center, Jiangsu Health Development Research Center, Nanjing 210000, Jiangsu Province, China
Ye-Fei Zhu, Laboratory Medicine Center, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China
Co-first authors: Lan-Lan Xiang and Jie Feng.
Co-corresponding authors: Ye-Fei Zhu and Yu Zeng.
Author contributions: Xiang LL and Feng J analyzed the data, interpreted the results, prepared the tables and figures, and edited the manuscript; they contributed equally as co-first authors; Li SY, Zhu YT, Chen YJ, and Zhong TY participated in the discussion and provided further editing and comments; Zhu YF and Zeng Y supervised the work, helped design the study, and reviewed the manuscript; they contributed equally as co-corresponding authors; All authors approved the final version.
Supported by Nanjing Medical Science and Technique Development Foundation, No. YKK23151; the Opening Foundation of Key Laboratory, No. JSHD202313; Yingke Xinchuang Research Foundation of Jiangsu Blood Transfusion Association, No. JSYK2024006; the Jiangsu Province Capability Improvement Project through Science, Technology and Education, No. ZDXYS202210; Open Project of the State Key Laboratory of Reproductive Medicine of Nanjing Medical University, No. SKLRM-K202107; and the Jiangsu Provincial Maternal and Child Health Research Program, No. F202040.
Institutional review board statement: This study followed the Declaration of Helsinki on medical protocols and ethics. The study was reviewed and approved by the Medical Ethics Committee of Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital (No. 2022KY-068).
Informed consent statement: Considering that this study was retrospective and that the data did not contain any personally identifiable data, the Medical Ethics Committee of Nanjing Women and Children’s Healthcare Hospital determined that the requirement for informed consent from participants was not applicable.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data that support the findings of this study are available from the corresponding author Yu Zeng upon reasonable request.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu Zeng, PhD, Professor, Department of Clinical Laboratory, Women’s Hospital of Nanjing Medical University, Nanjing Women and Children’s Healthcare Hospital, No. 123 Tianfei Lane, Mochou Road, Qinhuan District, Nanjing 210002, Jiangsu Province, China. zengyu@njmu.edu.cn
Received: December 18, 2024
Revised: April 2, 2025
Accepted: May 30, 2025
Published online: July 15, 2025
Processing time: 210 Days and 4.8 Hours
Core Tip

Core Tip: Large-for-gestational-age (LGA) infants are a primary complication associated with gestational diabetes mellitus. While maternal hyperglycemia is a recognized risk factor for LGA, it may not be the sole contributor. Epidemiological studies have indicated that abnormal lipid metabolism significantly contributes to insulin resistance, a key pathophysiological mechanism in gestational diabetes mellitus. However, the link between lipid indices and LGA infant risk remains contentious, with inconsistent findings across studies. Consequently, the aim of the study was to assess the association between maternal lipid indices and LGA infant risk in our cohort.