Review
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jun 15, 2025; 16(6): 105711
Published online Jun 15, 2025. doi: 10.4239/wjd.v16.i6.105711
Progress in the application of mesenchymal stem cells to attenuate apoptosis in diabetic kidney disease
Ping Nie, Wei Qin, Wei-Chen Nie, Bing Li
Ping Nie, Wei Qin, Bing Li, Department of Nephropathy, The Second Hospital of Jilin University, Changchun 130041, Jilin Province, China
Wei-Chen Nie, Basic Clinical Specialization in Integrative Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun 130117, Jilin Province, China
Author contributions: Nie P wrote the original draft; Qin W made the diagrams; Nie WC searched for information; Li B offered recommendations for improvement; All the prepared collaboratively the draft, and consented to the submitted version.
Supported by Science and Technology Research Program of Jilin Provincial Department of Education, No. JJKH20231218KJ; and Project of the Jilin Provincial Administration of Traditional Chinese Medicine, No. 2024111.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bing Li, Department of Nephropathy, The Second Hospital of Jilin University, No. 218 Ziqiang Street, Changchun 130041, Jilin Province, China. li_bing2020@jlu.edu.cn
Received: February 17, 2025
Revised: March 24, 2025
Accepted: April 25, 2025
Published online: June 15, 2025
Processing time: 117 Days and 8.6 Hours
Core Tip

Core Tip: Diabetic kidney disease (DKD) represents a prevalent and serious complication of diabetes. Mesenchymal stem cells (MSCs) and their extracellular vesicles (MSC-EVs) show promise for treating DKD by regulating apoptosis; however, challenges such as a lack of standardization, hinder their clinical application. This review examines the research progress on the roles of MSCs and MSC-EVs in this disease.