Copyright
©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2024; 15(12): 2394-2398
Published online Dec 15, 2024. doi: 10.4239/wjd.v15.i12.2394
Published online Dec 15, 2024. doi: 10.4239/wjd.v15.i12.2394
Role of intestinal glucagon-like peptide-1 in impaired counter-regulatory responses to hypoglycemia
Manjunath Havalappa Dodamani, Department of Endocrinology, Rukmini Hormone Superspeciality Hospital, Bagalkot 587101, Karnātaka, India
Juniali Hatwal, Department of Internal Medicine, Post Graduate Institute of Medical Education & Research, Chandigarh 160012, India
Akash Batta, Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India
Author contributions: Dodamani MH and Batta A designed the Editorial; Dodamani MH, Hatwal J, and Batta A performed the literature review and data collection; Dodamani MH and Batta A supervised the study and provided key feedback and suggestions; Dodamani MH analyzed the data, and wrote and revised the manuscript; All authors have read and approved the final manuscript.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Akash Batta, MD, Assistant Professor, Department of Cardiology, Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com
Received: July 28, 2024
Revised: October 8, 2024
Accepted: October 23, 2024
Published online: December 15, 2024
Processing time: 112 Days and 18.7 Hours
Revised: October 8, 2024
Accepted: October 23, 2024
Published online: December 15, 2024
Processing time: 112 Days and 18.7 Hours
Core Tip
Core Tip: Glucagon-like peptide-1 (GLP-1), an incretin hormone, plays an important role in blood glucose homeostasis, especially during the prandial phase. Excessive intestinal GLP-1 is correlated with reduced secretion of catecholamines and decreased appetite in type 1 diabetes mellitus mice exposed to recurrent hypoglycemic episodes resulting in impaired counter-regulatory responses to hypoglycemia. The index study of diabetic mice by Jin et al highlights the significant role of intestinal GLP-1 in impairment of hypoglycemia-induced counter-regulatory responses.