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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Jul 15, 2023; 14(7): 1126-1136
Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.1126
Published online Jul 15, 2023. doi: 10.4239/wjd.v14.i7.1126
Association between cardiorespiratory fitness level and insulin resistance in adolescents with various obesity categories
Lavinia La Grasta Sabolic, Marija Pozgaj Sepec, Bernardica Valent Moric, Department of Pediatric Endocrinology and Diabetology, University Hospital Centre Sestre milosrdnice, Zagreb 10000, Croatia
Lavinia La Grasta Sabolic, School of Medicine, Catholic University, Zagreb 10000, Croatia
Maja Cigrovski Berkovic, Department for Sport and Exercise Medicine, Faculty of Kinesiology University of Zagreb, Zagreb 10000, Croatia
Author contributions: Cigrovski Berkovic M made substantial contributions to conception of the study and revised the manuscript critically; La Grasta Sabolic L designed the study, participated in the acquisition, analysis, and interpretation of the data, and drafted the initial manuscript; Pozgaj Sepec M and Valent Moric B participated in the acquisition of the data and drafting of the manuscript.
Institutional review board statement: The study was reviewed and approved by the University Hospital Sestre milosrdnice Institutional Review Board (Approval No. EP-520/19-4).
Informed consent statement: All study participants, or their legal guardians, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare having no conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Lavinia La Grasta Sabolic, MD, Postdoctoral Fellow, Department of Pediatric Endocrinology and Diabetology, University Hospital Centre Sestre milosrdnice, 29 Vinogradska, Zagreb 10000, Croatia. lavinia.la.grasta.sabolic@gmail.com
Received: April 17, 2023
Peer-review started: April 17, 2023
First decision: May 15, 2023
Revised: May 22, 2023
Accepted: June 2, 2023
Article in press: June 2, 2023
Published online: July 15, 2023
Peer-review started: April 17, 2023
First decision: May 15, 2023
Revised: May 22, 2023
Accepted: June 2, 2023
Article in press: June 2, 2023
Published online: July 15, 2023
Core Tip
Core Tip: The association between obesity and insulin resistance is well established. However, data concerning the relationship between cardiorespiratory fitness (CRF) and insulin resistance in obese adolescents, especially in those with varying obesity categories, are quite limited. The results of present study show that obese adolescents with good CRF have lower homeostatic model assessment of insulin resistance (HOMA-IR) than obese adolescents with poor CRF. Moreover, there is no difference in HOMA-IR between severely obese adolescents with good CRF and mildly obese adolescents with poor CRF. Thus, the improvement of CRF in obese adolescents, including those with severe obesity, should be a therapeutic goal.