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Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Sep 15, 2022; 13(9): 696-716
Published online Sep 15, 2022. doi: 10.4239/wjd.v13.i9.696
Evolving spectrum of diabetic wound: Mechanistic insights and therapeutic targets
Raja Chakraborty, Pobitra Borah, Partha Pratim Dutta, Saikat Sen
Raja Chakraborty, Institute of Pharmacy, Assam Don Bosco University, Kamrup 782402, Assam, India
Pobitra Borah, School of Pharmacy, Graphic Era Hill University, Dehradun 248002, Uttarakhand, India
Partha Pratim Dutta, Saikat Sen, Faculty of Pharmaceutical Science, Assam down town University, Guwahati 781026, Assam, India
Author contributions: Chakraborty R, Borah P, Sen S, Dutta PP performed data accusation and writing; Borah P, Dutta PP prepared the figures; Chakraborty R provided the input in writing the paper; Sen S designed the outline and coordinated the writing of the paper.
Conflict-of-interest statement: There is no conflict of interest associated with any of the authors contributed their efforts in this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Saikat Sen, PhD, Professor, Faculty of Pharmaceutical Science, Assam down town University, Gandhinagar, Panikhaiti, Guwahati 781026, Assam, India. saikat.pharm@rediffmail.com
Received: May 1, 2022
Peer-review started: May 1, 2022
First decision: May 29, 2022
Revised: June 12, 2022
Accepted: August 15, 2022
Article in press: August 15, 2022
Published online: September 15, 2022
Core Tip

Core Tip: This paper reviewed molecular pathways and epigenetic mechanisms involved in the pathogenesis of diabetic wounds. The role of microbiota, oxidative stress, inflammatory cytokines, and alteration in the factors involved in normal wound healing process was highlighted. Molecular targets of therapeutic agents, the role of phytochemicals was discussed. The efficacy of several pharmacotherapy, treatment strategies, and recent clinical trials aiming to improve the outcome of diabetic foot ulcers was reviewed.