Genetics of macrovascular complications in type 2 diabetes

doi:10.4239/wjd.v12.i8.1200

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Diabetes. Aug 15, 2021; 12(8): 1200-1219
Published online Aug 15, 2021. doi: 10.4239/wjd.v12.i8.1200

Genetics of macrovascular complications in type 2 diabetes

Ziravard N Tonyan, Yulia A Nasykhova, Maria M Danilova, Andrey S Glotov

Ziravard N Tonyan, Yulia A Nasykhova, Maria M Danilova, Andrey S Glotov, Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint-Petersburg 199034, Russia

Yulia A Nasykhova, Andrey S Glotov, Laboratory of Biobanking and Genomic Medicine of Institute of Translation Biomedicine, St. Petersburg State University, Saint-Petersburg 199034, Russia

Author contributions: All authors contributed equally to the work.

Supported by Ministry of Science and Higher Education of the Russian Federation within the Applied Science Research Program, No. AAAA-A20-120041390028-0; and Estonia-Russia Cross Border Cooperation Programme 2014-2020, No. ER24.

Conflict-of-interest statement: The authors have no conflicts of interest to declare.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Andrey S Glotov, DSc, PhD, Senior Scientist, Department of Genomic Medicine, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Mendeleevskaya Line 3, Saint-Petersburg 199034, Russia. anglotov@mail.ru

Received: March 1, 2021
Peer-review started: March 1, 2021
First decision: April 20, 2021
Revised: May 4, 2021
Accepted: July 9, 2021
Article in press: July 9, 2021
Published online: August 15, 2021

Core Tip

Core Tip: Type 2 diabetes mellitus (T2DM) is often associated with life-threatening macrovascular complications which may lead to an eye injury, kidney failure, and reduction in life expectancy in patients with diabetes. This review is focused on genetic and epigenetic risk factors for macrovascular complications development in patients with T2DM.