Kuo FY, Cheng KC, Li Y, Cheng JT. Oral glucose tolerance test in diabetes, the old method revisited. World J Diabetes 2021; 12(6): 786-793 [PMID: 34168728 DOI: 10.4239/wjd.v12.i6.786]
Corresponding Author of This Article
Juei-Tang Cheng, PhD, Additional Professor, Department of Medical Research, Chi-Mei Medical Center, No. 901 Zhonghua Road, Yong Kang District, Tainan 71004, Taiwan. jtcheng5503@gmail.com
Research Domain of This Article
Methodology
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Feng Yu Kuo, Cardiovascular Center, Veterans General Hospital, Kaohsiung 82445, Taiwan
Kai-Chun Cheng, Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 90741, Taiwan
Kai-Chun Cheng, Pharmacological Department of Herbal Medicine and Department of Psychosomatic Internal Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan
Yingxiao Li, Department of Nursing, Tzu Chi University of Science and Technology, Hualien 973302, Taiwan
Juei-Tang Cheng, Department of Medical Research, Chi-Mei Medical Center, Tainan 71004, Taiwan
Author contributions: Kuo FY and Cheng KC designed the article; Kuo FY and Li Y collected the references and prepared the manuscript; Cheng JT revised the manuscript for important intellectual content; all authors read and approved the final manuscript.
Conflict-of-interest statement: No conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Juei-Tang Cheng, PhD, Additional Professor, Department of Medical Research, Chi-Mei Medical Center, No. 901 Zhonghua Road, Yong Kang District, Tainan 71004, Taiwan. jtcheng5503@gmail.com
Received: January 14, 2021 Peer-review started: January 14, 2021 First decision: February 12, 2021 Revised: February 24, 2021 Accepted: May 19, 2021 Article in press: May 19, 2021 Published online: June 15, 2021
Core Tip
Core Tip: Oral glucose tolerance test (OGTT) is a useful tool that has been applied from the last century to now. It is used to diagnose impaired glucose tolerance and/or type 2 diabetes mellitus in individuals. Basic research also applied it to investigate the glucose utilization and insulin sensitivity in animals. However, the main aim of each is quite different, and the details are also somewhat varied. In addition to the merits of OGTT in bench and bedside, variations between clinical practice and basic research are also discussed. Notably, recent reports have recommended that the time for OGTT be shorter in individuals. This conclusion needs to be confirmed officially in advance by diabetes associations. This new method is also required to be clarified in animal research. Additionally, perspectives of OGTT application are also conducted in this review including machine learning. Therefore, this report suggests a new way for OGTT practice in the future.
