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World J Diabetes. May 15, 2021; 12(5): 642-650
Published online May 15, 2021. doi: 10.4239/wjd.v12.i5.642
COVID-19 and hyperglycemia/diabetes
Konstantinos Michalakis, Ioannis Ilias
Konstantinos Michalakis, Private Practice, Athens GR-11521, Greece
Ioannis Ilias, Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, Athens GR-11521, Greece
Author contributions: Ilias I was the guarantor and planned the review; Ilias I and Michalakis K reviewed the literature and wrote the initial manuscript, conceived and drew the figure; Ilias I and Michalakis K critically revised the article for important intellectual content.
Conflict-of-interest statement: Nothing to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ioannis Ilias, MD, PhD, Consultant Physician-Scientist, Department of Endocrinology, Diabetes and Metabolism, Elena Venizelou Hospital, 2 Elena Venizelou Sq, Athens GR-11521, Greece. iiliasmd@yahoo.com
Received: January 19, 2021
Peer-review started: January 19, 2021
First decision: February 12, 2021
Revised: February 26, 2021
Accepted: April 20, 2021
Article in press: April 20, 2021
Published online: May 15, 2021
Core Tip

Core Tip: The severe acute respiratory syndrome coronavirus 2 pathogen has led to the coronavirus disease 2019 (COVID-19) pandemic. This virus exerts multi-organ actions after an initial respiratory infection. In early studies regarding COVID-19, type 2 diabetes mellitus was considered to contribute substantially to the disease’s inflammatory response. Hyperglycemia in COVID-19, irrespective of insulin resistance or history of diabetes, is a portent of worse prognosis. Further studies will help elucidate the link between glycemia and COVID-19.