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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. May 15, 2021; 12(5): 590-602
Published online May 15, 2021. doi: 10.4239/wjd.v12.i5.590
Published online May 15, 2021. doi: 10.4239/wjd.v12.i5.590
Advanced-glycation end-products axis: A contributor to the risk of severe illness from COVID-19 in diabetes patients
Armando Rojas, Ileana Gonzàlez, Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, Talca 3460000, Chile
Cristian Lindner, Medicine Faculty, Catholic University of Maule, Talca 3460000, Chile
Miguel Angel Morales, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, University of Chile, Santiago 8320000, Chile
Author contributions: All authors contributed to the original ideas and writing of this paper; Rojas A designed the report and wrote the paper; Lindner C contributed to data collection, draft manuscript preparation, and art-work; Gonzàlez I and Morales MA contributed to data acquisition, drafting, and revising the manuscript.
Conflict-of-interest statement: None of the authors declare a conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Armando Rojas, PhD, Full Professor, Biomedical Research Labs, Medicine Faculty, Catholic University of Maule, 3605 San Miguel Avenue, Talca 3605, Chile. arojasr@ucm.cl
Received: January 4, 2021
Peer-review started: January 4, 2021
First decision: January 25, 2021
Revised: January 29, 2021
Accepted: April 7, 2021
Article in press: April 7, 2021
Published online: May 15, 2021
Peer-review started: January 4, 2021
First decision: January 25, 2021
Revised: January 29, 2021
Accepted: April 7, 2021
Article in press: April 7, 2021
Published online: May 15, 2021
Core Tip
Core Tip: Compelling evidence support that diabetes mellitus increases the risk of coronavirus disease 2019 (COVID-19) complications, as well as the overall syndrome coronavirus 2 case-fatality. Different reports have suggested the putative involvement of several molecular mechanisms underlying this increased risk. We herein discuss the contribution of the activation of the receptor for advanced-glycation end-products axis to the higher risk for severe illness reported in diabetes patients with COVID-19.