Published online Apr 15, 2021. doi: 10.4239/wjd.v12.i4.420
Peer-review started: January 12, 2021
First decision: February 12, 2021
Revised: February 22, 2021
Accepted: March 29, 2021
Article in press: March 29, 2021
Published online: April 15, 2021
Core Tip: Multiple independent observations have led to the concept of the metabolically healthy obese (MHO) phenotype, in which individuals, despite a high body mass index, remain normoglycemic, insulin sensitive, and hypotensive with proper blood lipid levels. Even though this issue is of great interest to the scientific community, no consensus has been reached to date regarding the main mechanism behind this phenomenon. The aim of this review is to present the current status regarding the use of omics technologies to investigate the MHO phenotype at different molecular levels, as well as the results of targeted analyses conducted in MHO individuals.