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World J Diabetes. Apr 15, 2021; 12(4): 420-436
Published online Apr 15, 2021. doi: 10.4239/wjd.v12.i4.420
Obesity, metabolic health and omics: Current status and future directions
Magdalena Paczkowska-Abdulsalam, Adam Kretowski
Magdalena Paczkowska-Abdulsalam, Adam Kretowski, Clinical Research Centre, Medical University of Bialystok, Bialystok 15-276, Poland
Adam Kretowski, Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok 15-276, Poland
Author contributions: Paczkowska-Abdulsalam M performed the literature review and wrote the manuscript which was critically revised for important intellectual content by Kretowski A; both authors approved the final version of the article.
Conflict-of-interest statement: Authors have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Magdalena Paczkowska-Abdulsalam, PhD, Research Fellow, Clinical Research Centre, Medical University of Bialystok, Sklodowskiej-Curie 24A, Bialystok 15-276, Poland. magdalena.paczkowska@umb.edu.pl
Received: January 12, 2021
Peer-review started: January 12, 2021
First decision: February 12, 2021
Revised: February 22, 2021
Accepted: March 29, 2021
Article in press: March 29, 2021
Published online: April 15, 2021
Core Tip

Core Tip: Multiple independent observations have led to the concept of the metabolically healthy obese (MHO) phenotype, in which individuals, despite a high body mass index, remain normoglycemic, insulin sensitive, and hypotensive with proper blood lipid levels. Even though this issue is of great interest to the scientific community, no consensus has been reached to date regarding the main mechanism behind this phenomenon. The aim of this review is to present the current status regarding the use of omics technologies to investigate the MHO phenotype at different molecular levels, as well as the results of targeted analyses conducted in MHO individuals.