Basic Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Diabetes. Dec 15, 2021; 12(12): 2050-2057
Published online Dec 15, 2021. doi: 10.4239/wjd.v12.i12.2050
Inhibitory effect of maspinon neovascularization in diabetic retinopathy
Feng Qiu, Hui-Juan Tong
Feng Qiu, Department of Ophthalmology, Shenyang Fourth People’s Hospital, Shenyang 110031, Liaoning Province, China
Hui-Juan Tong, Department of Nursing, Shenyang Medical College, Shenyang 110034, Liaoning Province, China
Author contributions: Qiu F was involved in the data curation and writing of the original draft; Tong HJ performed the data curation and formal analysis, and participated in the writing and editing of the manuscript; All authors have read and approved the final.
Supported by Liaoning Province Natural Science Foundation, No. 2020-BS-277.
Institutional animal care and use committee statement: The study was reviewed and approved by Shenyang Fourth People’s Hospital Institutional Review Board.
Conflict-of-interest statement: The authors declare that they have no conflicting interests.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Juan Tong, PhD, Assistant Professor, Department of Nursing, Shenyang Medical College, No. 146 North Huanghe Avenue, Shenyang 110034, Liaoning Province, China. thj_9921@163.com
Received: July 7, 2021
Peer-review started: July 7, 2021
First decision: July 28, 2021
Revised: August 9, 2021
Accepted: December 8, 2021
Article in press: December 8, 2021
Published online: December 15, 2021
Core Tip

Core Tip: The aim of our study was to evaluate the effectiveness of intravitreal injection of recombinant human maspin on neovascularization in diabetic retinopathy. A mouse model of oxygen-induced retinopathy was used to simulate neovascularization in diabetic retinopathy. Maspin inhibited neovascularization in this model by modulating the hypoxia-inducible factor 1-alpha/vascular endothelial growth factor pathway, which provides a potential and effective strategy for the treatment of diabetic retinopathy.